Dr. Wei Zhou's group engineers Hybrid Optical-Electrical Nano-Bio Interface—integrated platform technology for real-time biosensing and actuation—to address critical needs in health, agricultural, and environmental sectors. Combining hybrid micro-/nanofabrication, optical nanocavities, micro-/nanoelectrodes, and machine learning analytics, we create multimodal nano-bio interfacing devices for continuous biochemical-biophysical monitoring and actuation. These devices enable proactive healthcare through early disease interception and real-time therapeutics, alongside precise neuromodulation and field-deployable environmental and agricultural monitoring. Our ultimate goal is to transform reactive diagnostics and treatments into proactive, personalized, and sustainable solutions by integrating nanophotonics-nanoelectronics breakthroughs with data-driven precision.